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First total synthesis of the antitumor compound (-)-kazusamycin A and absolute structure determination
Authors:Arai Noriyoshi  Chikaraishi Noriko  Omura Satoshi  Kuwajima Isao
Institution:Creation and Function of New Molecules and Molecular Assemblies, Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan.
Abstract:The first total synthesis of kazusamycin A, a potent antitumor compound from an actinomycete, has been achieved, and its absolute structure was determined. Paterson's stereoselective aldol reaction was successfully applied to construct the contiguous chiral centers by using an originally designed optically active 2-acyl-1,3-propanediol derivative.
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