Synthesis, characterization and preliminary toxicity assays of NIR-active Au-silicate nanoparticles through a sol-gel processing |
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Authors: | Lei Ren Qi-Qing Zhang Gan-Moog Chow |
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Institution: | (1) Research Center of Biomedical Engineering, Medical College, Xiamen University, Xiamen, 361005, P.R. China;(2) Department of Materials Science and Engineering, National University of Singapore, Singapore, 119260 |
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Abstract: | Monodisperse Au-silicate nanoparticles (10.7±1.6 nm in diameter) were prepared by reduction of aqueous solution containing
2 mM HAuCl4 with sodium citrate (1 wt.%) in a hydrosol, in which small clusters of silicate formed by hydrolysis and polymerization of
3-aminopropyltrimethoxysilane (APTMS). APTMS covalently linked to reduced gold particles through its -NH2 end-group. UV-vis spectra of the obtained Au-silicate nanoparticles showed a peak at ∼690 nm due to the interface effects
between the Au and the silicate matrix. The Au-silicate nanoparticles exhibited near-IR (NIR) sensitivity. Cytotoxicity and
limited hemocompatibility in vitro for the prepared Au-silicate nanoparticles were also investigated. It was shown that at lower concentration (<1 μg/ml), the
Au-silicate nanoparticles were biocompatible without causing any cytotoxicity and hemolysis. |
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Keywords: | Biomaterials Nano-hybrids Sol-gel growth Optical properties Toxicity |
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