Synthesis and biodistribution of a novel 99mTc nitrido radiopharmaceutical with proline dithiocarbamate as a potential tumor imaging agent |
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Authors: | Miao Liu Xiao Lin Xiaoqing Song Yang Cui Peiwen Li Xuebin Wang Junbo Zhang |
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Institution: | 1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, 100875, People’s Republic of China
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Abstract: | In the present study, proline dithiocarbamate (PRODTC) ligand was radiolabeled with the 99mTc≡N]2+ core successfully to obtain the 99mTcN-PRODTC complex with high radiochemical purity. No decomposition of the complex at room temperature was observed over a period of 6 h. Its partition coefficient indicated that it was a hydrophilic complex. The electrophoresis results showed that the complex was negative. The biodistribution of 99mTcN-PRODTC in mice bearing S 180 tumor showed that the complex accumulated in the tumor with a certain uptake. The tumor/blood and tumor/muscle ratios reached 2.19 and 4.54 at 2 h post-injection, suggesting it would be a promising candidate for tumor imaging. |
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