A one-step fully automated radio-synthesis of a dopamine transporter PET imaging agent 18F-FECNT and its in vivo evaluations |
| |
| Authors: | Sheng Liang Zhengping Chen Yufei Ma Jun Guo Hui Wang |
| |
| Institution: | 1. Department of Nuclear Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, 1665 Kongjiang Rd., Shanghai, 200092, People’s Republic of China
2. The Key Laboratory of Nuclear Medicine, Ministry of Health PRC, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, People’s Republic of China
|
| |
| Abstract: | 2β-Carbomethoxy-3β-(4-chlorophenyl)-8-(2-18F]fluoroethyl)nortropane (18F]-FECNT) is a potential dopamine transporter PET imaging agent. However, its current radio-synthesis is tedious and time consuming. In this article, we reported a fully automatic method for the synthesis of 18F] FECNT through only one step, using a TRACERlab FXN module, with decay corrected radiochemical yield of 25 ± 5 % (n = 5). The total synthesis time was 50–55 min. The synthesized 18F]FECNT was evaluated in vivo in Parkinson’s disease model rats. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
