|
|||||
|
|
| 2-氨基-3-氰基-4-芳基-6-甲氧基-1,4,9,10-四氢萘并[2,1-b]吡喃衍生物的一步合成 | |
| 引用本文： | 王香善,史达清,魏贤勇,宗志敏.2-氨基-3-氰基-4-芳基-6-甲氧基-1,4,9,10-四氢萘并[2,1-b]吡喃衍生物的一步合成[J].有机化学,2004,24(11):1454-1457. |
| 作者姓名： | 王香善 史达清 魏贤勇 宗志敏 |
| 作者单位： | 1. 徐州师范大学化学系,徐州,221116;中国矿业大学化学工程学院,徐州,221008;江苏省药用植物生物技术重点实验室,徐州,221116 2. 徐州师范大学化学系,徐州,221116;江苏省药用植物生物技术重点实验室,徐州,221116 3. 中国矿业大学化学工程学院,徐州,221008 |
| 基金项目： | 江苏省教育厅青蓝工程项目，江苏省教育厅高校自然科学基金 |
| 摘 要： | 以芳醛、丙二腈和7-甲氧基-1,2,3,4-四氢萘-2-酮为原料,在六氢吡啶催化下以乙醇为溶剂,在室温合成了一系列新的2-氨基-3-氰基-4-芳基-6-甲氧基-1,4,9,10-四氢萘并2,1-b]吡喃衍生物,反应条件温和,产率较高,并通过IR,1H NMR和元素分析表征产物的结构,还通过单晶X射线衍射分析确证产物的构象. |
| 关 键 词： | 7-甲氧基-2-萘酮 六氢吡啶 萘并[1 2-b]吡喃 合成 |
| 修稿时间： | 2004年1月13日 |
One-Step Synthesis of 2-Amino-3-cyano-4-aryl-6-methoxy-1,4,9,10- tetrahydronaphtho[ 2,1-b ] pyran Derivatives |
|
| WANG,Xiang-Shan,a,b,c SHI,Da-Qing a,c WEI,Xian-Yong b ZONG,Zhi-Min b.One-Step Synthesis of 2-Amino-3-cyano-4-aryl-6-methoxy-1,4,9,10- tetrahydronaphtho[ 2,1-b ] pyran Derivatives[J].Chinese Journal of Organic Chemistry,2004,24(11):1454-1457. | |
| Authors: | WANG Xiang-Shan a b c SHI Da-Qing a c WEI Xian-Yong b ZONG Zhi-Min b |
| Abstract: | Using piperidine as catalyst and ethanol as solvent, a series of new 2-amino-3-cyano-4-aryl-6-methoxy-1,4,9,10-tetrahydronaphtho2,1-b]pyran derivatives were synthesized by one-pot reaction of aromatic aldehydes, malononitrile and 7-methoxy-1,2,3,4-tetrahydronaphthalen-2-one at room temperature in good yields. The reaction conditions were mild. The structures of the products were characterized by IR, 1H NMR spectra and elemental analysis. The conformation of compound 4a was also confirmed by X-ray analysis. |
| Keywords: | methoxylnaphthalen-2-one piperidine naphtho[2 1-b]pyran synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |