O-乙基-N-异丙基(取代硫脲基)硫代磷酰胺酯类衍生物杀菌作用的构效关系研究

研究了一系列O-乙基-N-异丙基(取代硫脲基)硫代磷酰胺酯类化合物的杀菌活性,发现分子的活性中心在硫脲基上,其氮原子上所连的取代基对活性有重要影响。采用取代基物理参数及化合物对多种植物病菌的抑制活性,进行了结构与活性定量关系的研究。建立了较好的结构与活性的相关式,预测出更高活性的化合物并得到实验证实。

Quantitative Structure Activity Relationship Study of FungicidalO- Ethyl-N-isopropylphosphoro(thioureido) thioates

The fungicidal activity of a series of O-ethyl-N-isopropylphosphoro(thioureido) thioates was studied. It was found that the activity of these compounds was highly dependent upon the substituents attached to the nitrogen atom and this is a kind of broad spectrum fungicide.The quantitative relationship between the structure of the compounds and their fungicidal activity on the rice sheeth blight (Pellicularia sasakii),wheat bead blight (Gib berella saubinetii ), apple alternaria fruit rot (Alternalia mali), cotton soreshin (Rhizoolonia solani),and cercospora spot of sugar beet (Cercospora belocola) were analyzed,respectively,using the physicochemical parametres of the substituents and regression analysis.The re sults were used in guiding the synthesis of higher active compound and verified.