Medium-dependent electron and H atom transfer between 2'-deoxyadenosine and menadione: a magnetic field effect study |
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Authors: | Sengupta Tamal Dutta Choudhury Sharmistha Basu Samita |
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Affiliation: | Chemical Sciences Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700 064, India. |
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Abstract: | The interaction between 2'-deoxyadenosine and the model antitumor drug menadione has been studied in organic solvent and in micellar medium. The aim of the work is to elucidate the mechanism of this drug-nucleoside interaction and to determine the environmental effects. Laser flash photolysis and magnetic field effect are used to detect the transients and their spin states. The results indicate that H atom transfer and electron transfer are the operative mechanisms depending upon the medium. |
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