First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes |
| |
| Authors: | Scaglione Jamie B Rath Nigam P Covey Douglas F |
| |
| Affiliation: | Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MI 63110, USA. |
| |
| Abstract: | An enantiospecific route to the previously unreported 1,6-difunctionalized dodecahydrobenz[f]indene ring system is described. Optically pure Hajos-Parrish ketone is used as the building block for preparation of a 6-methyleneinden-5-ol. This allylic alcohol is then utilized in a Claisen rearrangement under Johnson's conditions to introduce a side chain that is further modified and cyclized to produce the benz[f]indene ring system. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
