药物释放环境对层状复合氢氧化物载体的影响

以层状复合氢氧化物(LDH)为载体用离子交换法制取乙酰苯甲酸(ASP)的插层复合物LDH-ASP, 通过体外释放实验和固相XRD、FT-IR、TEM、TG-DSC及BET-N2比表面积表征, 研究了药物释放环境对载体结构的影响. 结果表明释放环境pH为4.30-6.89时, 载体的层状特征减弱但晶体类型不变; pH为2.48-4.30时, H2PO-4对LDH的嫁接反应引起层状化合物向复杂磷酸盐转化; 随环境pH由6.89降低至2.48, 载体纯度下降, 晶态性征减弱,微孔吸附活性降低.

Effects of Drug Release Medium on Layered Double Hydroxide Carrier

Layered double hydroxide (LDH) had been used as a carrier of acetylsalicylic acid (ASP) to prepare intercalation compound LDH-ASP via ion exchange reaction. The influence of release medium on the carrier was investigated through extrinsic release test and XRD, FT-IR, TEM, TG-DSC, and BET-N2 surface area characterizations. The results showed that the carrier’s laminar features weakened in a pH range from 4.30 to 6.89, but the LDH crystal-class kept unchanged. In a pH range from 2.48 to 4.30, the probable grating reaction between H2PO-4 and hydroxyls of LDH caused laminar carrier transformation into complex phosphates. Along with pH decreased from 6.89 to 2.48, the carrier’s purity decreased, crystallinity weakened, and micro-pore absorbability declined.