| 猪去氧胆酸化学7.(24R)-24,25-双羟基,(24R,25S)-24,25,26-三羟基和(25R)-25,26-双羟基胆固醇的立体选择性和区域选择性合成 |
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| 引用本文： | 王钟麒,阮奔放.猪去氧胆酸化学7.(24R)-24,25-双羟基,(24R,25S)-24,25,26-三羟基和(25R)-25,26-双羟基胆固醇的立体选择性和区域选择性合成[J].化学学报,1994,52(4):403-411. |
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| 作者姓名： | 王钟麒 阮奔放 |
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| 作者单位： | 中国科学院上海有机化学研究所 |
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| 基金项目： | 国家自然科学基金资助的课题 |
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| 摘 要： | 本文报道以猪去氧胆酸甲酯(2a)为原料, 立体选择和区域选择性地合成了维生素D~3代谢产物及类似物的关键中间体(24O)-24,25-双羟基胆固醇(3b),(24O,25, 26-三羟基胆固醇(3c)和(25O)-25,26-双羟基胆固醇(3d).,总收率分别为27,27和38%.
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| 关 键 词： | 代谢物 立体选择性 胆酸 猪去氧胆酸 胆固醇 区域选择性 |
Chemistry of hyodeoxycholic acid. 7. stereo- and regio-selective syntheses of (24R)-24,25-dihydroxy-, (24R,25S)-24,25,26-trihydroxy-and(25R)-25,26-dihydrxycholesterol |
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| WANG ZHONGQI,RUAN BENFANG.Chemistry of hyodeoxycholic acid. 7. stereo- and regio-selective syntheses of (24R)-24,25-dihydroxy-, (24R,25S)-24,25,26-trihydroxy-and(25R)-25,26-dihydrxycholesterol[J].Acta Chimica Sinica,1994,52(4):403-411. |
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| Authors: | WANG ZHONGQI RUAN BENFANG |
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| Abstract: | (24R)-24,25-dihydroxycholesterol, (24R,25S)-24,25,26-trihydroxycholesterol, and (25R)-25,26-dihydroxycholesterol were prepared in 27, 27, and 38% yield resp. from Me hyodeoxycholanate. The key steps are stereoselective epoxidn. of the allylic alcohol I and regioselective ring opening process of the epoxy alcohol II. |
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| Keywords: | METABOLITE STEREOSELECTIVITY BILE ACID HYODEOXYCHOLIC ACID CHOLESTEROL REGIOSELECTIVITY |
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