Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles |
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Authors: | Hyeongsu Kim Dr Zi Xuan Dr?Prof Ju Hyun Kim |
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Institution: | Department of Chemistry (BK 21 four), Research Institute of Natural Science (RINS), Gyeongsang National University, 52828 Jinju, Gyeongnam, Korea) E-mail |
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Abstract: | An efficient tandem route to obtain tetrasubstituted NH pyrroles in a one-pot manner has been developed, staring from simple nitriles, ethyl bromoacetates, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of β-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles in yields up to 91%. |
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Keywords: | tetrasubstituted pyrroles nitriles Blaise reaction oxidative dimerization tandem reaction |
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