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Ultrasound-Enhanced Self-Exciting Photodynamic Therapy Based on Hypocrellin B |
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| Authors: | Ying Ding Dr. Weimin Liu Dr. Jiasheng Wu Dr. Xiuli Zheng Prof. Jiechao Ge Dr. Haohui Ren Prof. Wenjun Zhang Prof. Chun-Sing Lee Prof. Pengfei Wang |
| Affiliation: | 1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190 P. R. China School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China;2. Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190 P. R. China;3. Center Of Super-Diamond and Advanced Films (COSDAF) & Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong SAR, P. R. China |
| Abstract: | Peroxalate CL as an energy source to excite photosensitizers has attracted tremendous attention in photodynamic therapy (PDT). In this work, peroxyoxalate CPPO and hypocrellin B (HB)-based nanoparticles (CBNPs) for ultrasound (US)-enhanced self-exciting PDT were designed and prepared. CBNPs showed an excellent therapeutic effect against cancer cells with the assistance of US. This US-enhanced-chemiluminescence system avoids the dependence on external light and provides an example for inspiring more effective and precise strategies for cancer treatment. |
| Keywords: | Self-exciting photodynamic therapy Ultrasound-enhanced chemiluminescence Peroxyoxalate Hypocrellin B |