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Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides |
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| Authors: | Han Li Jie Sheng Bing-Bing Wu Yan Li Prof. Dr. Xi-Sheng Wang |
| Affiliation: | 1. Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemical, University of Science and Technology of China, Hefei, Anhui, 230026 P. R. China These authors contributed equally.;2. Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemical, University of Science and Technology of China, Hefei, Anhui, 230026 P. R. China |
| Abstract: | A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent ethyl chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process. |
| Keywords: | monofluoroacetation aryl halides ethyl chlorofluoroacetate nickel cross-coupling |