In Vitro Anticancer Activity of Nanoformulated Mono- and Di-nuclear Pt Compounds |
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| Authors: | Pan Wang Dr Jian-Wei Wang Prof Wen-Hua Zhang Dr Hongzhen Bai Prof Guping Tang Prof David J Young |
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| Institution: | 1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 P. R. China;2. Department of Chemistry, Zhejiang University, Hangzhou, 310028 P. R. China;3. College of Engineering Information Technology & Environment, Charles Darwin University, Darwin, Northern Territory, 0909 Australia |
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| Abstract: | Nanoformulations of mononuclear Pt complexes cis-PtCl2(PPh3)2 ( 1 ), Pt(PPh3)2(L−Cys)] ⋅ H2O ( 3 , L−Cys=L-cysteinate), trans-PtCl2(PPh2PhNMe2)2 ( 4 ; PPh2PhNMe2=4-(dimethylamine)triphenylphosphine), trans-PtI2(PPh2PhNMe2)2 ( 5 ) and dinuclear Pt cluster Pt2(μ-S)2(PPh3)4 ( 2 ) have comparable cytotoxicity to cisplatin against murine melanoma cell line B16F10. Masking of these discrete molecular entities within the hydrophobic core of Pluronic® F-127 significantly boosted their solubility and stability, ensuring efficient cellular uptake, giving in vitro IC50 values in the range of 0.87–11.23 μM. These results highlight the potential therapeutic value of Pt complexes featuring stable Pt−P bonds in nanocomposite formulations with biocompatible amphiphilic polymers. |
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| Keywords: | anticancer drug Pt drugs B16F10 Pt−S cluster crystal structure trans effect |
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