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Redirecting Cisplatin and Doxorubicin to Mitochondria Affords Highly Effective PlatinumIV Prodrug Against Triple Negative Breast Cancer |
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| Authors: | Dr. Nafees Muhammad Prof. Tan Cai-Ping Dr. Sadia Nasreen Prof. Zong-Wan Mao |
| Affiliation: | 1. School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275 P. R. China;2. Department of Environmental Engineering, University of Engineering and Technology (UET), Taxila, Taxila, 47080 Pakistan |
| Abstract: | A mitochondria targeting dual-action platinumIV prodrug exhibits high anticancer activity in triple negative breast cancer cells. The complex intervenes in several cellular processes including DNA damage, perturbation of mitochondrial bioenergetics and induction of necrosis to kill cancer cells. |
| Keywords: | PlatinumIV Doxorubicin Triple negative breast cancer Mitochondria Necrosis |