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A New Potent Antimicrobial Metalloporphyrin |
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| Authors: | Dr. Lu Jiang Pei Lin Chee Jian Gao Dr. Ching Ruey Raymond Gan Cally Owh Prof. Dr. Rajamani Lakshminarayanan Dr. Shan Jiang Prof. Dr. T. S. Andy Hor Prof. Dr. Xian Jun Loh |
| Affiliation: | 1. Institute of Materials Research and Engineering, Agency for Science, Technology and Research, 2 Fusionopolis Way, #08-03, Innovis, Singapore, 138634 Singapore;2. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Singapore;3. Anti-Infectives Research Group, Singapore Eye Research Institute, Singapore, 169856 Singapore Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, 169857 Singapore Department of Pharmacy, National University of Singapore, Singapore, 117543 Singapore;4. College of Chemistry, Jilin University, Changchun, 130012 P. R. China |
| Abstract: | A series of bis-acryl functionalized porphyrins and their corresponding metalloporphyrins (M=Co, Mn) were synthesized and investigated for their antimicrobial properties through MIC screening and bacteria time-kill kinetic studies. The Mn(III) 4-(bis)methylphenyl-substituted-porphyrins showed superior batericidal activities even in the dark with low hemotoxicity and good cytotoxicity profile. |
| Keywords: | antimicrobial agents metalloporphyrins organometallic porphyrin |