Polyelectrolyte/Gold Nanoparticle Nanotubes Incorporating Doxorubicin-Loaded Liposomes |
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| Authors: | Yuto Enomoto Dr. Motofusa Akiyama Dr. Yoshitsugu Morita Prof. Dr. Teruyuki Komatsu |
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| Affiliation: | Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo, 112-8551 Japan |
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| Abstract: | Anticancer agent doxorubicin-loaded liposomes (DoxLs) were drawn spontaneously into nanotubes comprising multilayers of polyelectrolytes and gold nanoparticles (PAuNTs). We describe a unique structure of PAuNTs incorporating DoxLs (DoxL-PAuNT). The number of DoxLs adsorbed on the tube interior surface was ascertained as 2.4×103. Heating stimuli engendered gel-liquid crystal phase transition of DoxL in the capillary, subsequently inducing efficient release of Dox without structural changes of the tubule or liposome. Furthermore, antitumor activity of the DoxL-PAuNTs on cancer cells was elucidated. |
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| Keywords: | anticancer agents layer-by-layer assembly nanostructures nanotubes template synthesis |
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