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Visible-Light-Driven Sulfonylation/Cyclization to Access Sulfonylated Benzo[4,5]imidazo[2,1-a]isoquinolin-6(5H)-ones |
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| Authors: | Chen Wang Guoquan Sun Hong-Li Huang Jing Liu Hua Tang Yinghua Li Dr Honggang Hu Shipeng He Fei Gao |
| Institution: | 1. Institute of Translation Medicine, Shanghai University, Shanghai, 200444 P. R. China
Chen Wang and Guoquan Sun contributed equally.;2. Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092 P. R. China Chen Wang and Guoquan Sun contributed equally.;3. College of Chemistry and Chemical Engineering, Liaocheng University, Shandong, 252059 P. R. China;4. Institute of Translation Medicine, Shanghai University, Shanghai, 200444 P. R. China |
| Abstract: | Visible-light-driven sulfonylation/cyclization of N-methacryloyl-2-phenylbenzoimidazoles has been successfully developed. Using commercially available sulfonyl chloride as sulfonylation reagent, a wide range of sulfonylated benzo4,5]imidazo2,1-a]isoquinolin-6(5H)-ones with potential antitumor activity were provided in acceptable to excellent yields. This method has the advantages of mild reaction conditions and outstanding functional group tolerance, and provides a new strategy for the development of potential antitumor lead compounds. |
| Keywords: | visible light photoredox catalysis radical cascade cyclization sulfonylation sulfonylated benzo[4 5]imidaz-o[2 1-a]isoquinolin-6(5H)-ones |