Synthesis of Poly-Substituted Pyridines via Noble-Metal-Free Cycloaddition of Ketones and Imines |
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| Authors: | Yeting Mao Hong Mao Jiaojiao Xu Tianqi Liu Dr. Bingxin Liu Prof. Dr. Qitao Tan Dr. Chang-Hua Ding Prof. Dr. Bin Xu |
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| Affiliation: | Department of Chemistry, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai Engineering Research Center of Organ Repair, Innovative Drug Research Center, School of Medicine, Shanghai University, Shanghai, 200444 P. R. China |
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| Abstract: | An eco-friendly and noble-metal-free formal [4+2] cycloaddition reaction was developed for the efficient synthesis of biologically interesting poly-substituted pyridines from easily available ketones and imines, whereby two sequential C−C bonds are formed. The given approach features a unique synthetic strategy of imines and ketones with wide substrate scope, good functional group tolerance, mild conditions and operational simplicity, which represents a more direct pathway to synthesize poly-substituted pyridines than traditional methods. |
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| Keywords: | substituted pyridine formal [4+2] cycloaddition ketone imine noble-metal-free |
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