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I2-Promoted Intramolecular Oxidative Cyclization of Butenyl Anilines: A Facile Route to Benzo[b]azepines |
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| Authors: | Zhenyu An Yi Ren Yafeng Liu Prof. Dr. Rulong Yan |
| Affiliation: | 1. State Key Laboratory of Applied Organic Chemistry, Key laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China These authors contribute equally to this work.;2. Chemical Science and Engineering College, North Minzu University, Yinchuan, 750000 P. R. China;3. State Key Laboratory of Applied Organic Chemistry, Key laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000 P. R. China |
| Abstract: | A metal-free approach for the synthesis of seven-membered N-heterocycles has been developed by the I2-promoted intramolecular cross-coupling/annulation of butenyl anilines. This cyclization reaction involves C−H activation and C−C bond formation and exhibits good functional group tolerance. A series of benzo[b]azepine derivatives are obtained in moderate to good yields. |
| Keywords: | Butenyl anilines Benzo[b]azepines I2-promoted Intramolecular annulation Metal-free |