Synthesis of Sulfonylated Heterocycles via Copper-Catalyzed Heteroaromatization/Sulfonyl Transfer of Propargylic Alcohols |
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| Authors: | Xinyi Chen Andrey Shatskiy Jian-Quan Liu Markus D Kärkäs Xiang-Shan Wang |
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| Institution: | 1. School of Chemistry and Materials Science, Jiangsu Key Laboratory of Green Synthesis for Functional Materials Jiangsu Normal University, 221116 Xuzhou, Jiangsu, P. R. China;2. Department of Chemistry, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden |
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| Abstract: | An unprecedented copper-catalyzed heteroaromatization/sulfonyl transfer of propargylic alcohols with isocyanide has been developed. 3-Sulfonyl benzofurans and indoles were produced under Cu(I) catalysis in good to high yields. The developed catalytic methodology provides controlled, modular, and facile access to sulfonyl benzoheterocycle scaffolds. |
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| Keywords: | Propargylic alcohols Copper Isocyanides Deoxysulfonylation Heterocycles |
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