Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus |
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| Authors: | Stephan Michel Jason Itri Jung H Han Kathryn Gniotczynski Christopher S Colwell |
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| Institution: | (1) Department of Molecular Cell Biology, Laboratory for Neurophysiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands;(2) Department of Psychiatry and Biobehavioral Sciences, University of California –, 760 Westwood Plaza, 90024-1759 Los Angeles, California, USA |
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| Abstract: | Background Previous studies indicate that light information reaches the suprachiasmatic nucleus (SCN) through a subpopulation of retinal
ganglion cells that contain both glutamate and pituitary adenylyl cyclase activating peptide (PACAP). While the role of glutamate
in this pathway has been well studied, the involvement of PACAP and its receptors are only beginning to be understood. Speculating
that PACAP may function to modulate how neurons in the suprachiasmatic nucleus respond to glutamate, we used electrophysiological
and calcium imaging tools to examine possible cellular interactions between these co-transmitters. |
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