Highly efficient one-pot synthesis of tetrahydropyridines |
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Authors: | Ghorbani-Vaghei Ramin Shahbazi Hajar |
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Institution: | Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 65174 Hamedan, Iran |
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Abstract: | The combination of aromatic aldehydes, and 1,3-dicarbonyl compounds in the presence of a catalytic amount of poly(N,N′-dibromo-N-ethyl-benzene-1,3-disulfonamide) PBBS] and N,N,N′,N′-tetrabromobenzene-1,3-disulfonamide TBBDA] leads to the formation of highly substituted tetrahydropyridines. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to high yields at room temperature. |
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Keywords: | Multicomponent reaction One-pot TBBDA PBBS Tetrahydropyridines Heterocycles |
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