Pulsed-field separation of particles in a microfluidic device |
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Authors: | J. Regtmeier R. Eichhorn T. T. Duong P. Reimann D. Anselmetti A. Ros |
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Affiliation: | (1) Experimental Biophysics & Applied Nanosciences, Bielefeld University, 33615 Bielefeld, Germany;(2) Theoretical Physics, Bielefeld University, 33615 Bielefeld, Germany |
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Abstract: | We demonstrate the proof-of-principle of a new separation concept for micrometer-sized particles in a structured microfluidic device. Under the action of externally applied, periodic voltage-pulses two different species of like-charged polystyrene beads are observed to simultaneously migrate into opposite directions. Based on a theoretical model of the particle motion in the microdevice that shows good agreement with the experimental measurements, the underlying separation mechanism is identified and explained. Potential biophysical applications, such as cell sorting, are briefly addressed. |
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Keywords: | 85.85.+j Micro- and nano-electromechanical systems (MEMS/NEMS) and devices 05.40.-a Fluctuation phenomena, random processes, noise, and Brownian motion 05.60.-k Transport processes 82.70.Dd Colloids |
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