Genomic regulation of natural variation in cortical and noncortical brain volume |
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Authors: | Jackson Beatty Rick E Laughlin |
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Institution: | (1) Department of Psychology, University of California Los Angeles, Los Angeles, California, USA |
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Abstract: | Background The relative growth of the neocortex parallels the emergence of complex cognitive functions across species. To determine the
regions of the mammalian genome responsible for natural variations in cortical volume, we conducted a complex trait analysis
using 34 strains of recombinant inbred (Rl) strains of mice (BXD), as well as their two parental strains (C57BL/6J and DBA/2J).
We measured both neocortical volume and total brain volume in 155 coronally sectioned mouse brains that were Nissl stained
and embedded in celloidin. After correction for shrinkage, the measured cortical and noncortical brain volumes were entered
into a multiple regression analysis, which removed the effects of body size and age from the measurements. Marker regression
and interval mapping were computed using WebQTL. |
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