A new approach to the synthesis of lamotrigine and other 3,5-diamino-1,2,4-triazine derivatives |
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| Authors: | E N Ulomskii T S Shestakova S L Deev V L Rusinov O N Chupakhin |
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| Institution: | (1) Ural State Technical University, 19 ul. Mira, 620002 Ekaterinburg, Russian Federation;(2) I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 20 ul. S. Kovalevskoi, 620219 Ekaterinburg, Russian Federation |
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| Abstract: | A new in principle method for the synthesis of 6-aryl(hetaryl)-3,5-diamino-1,2,4-triazines by decomposition of pre-synthesized tetrazolo1,5-b]1,2,4]triazines was developed. The advantages of this method over traditional methods were demonstrated using the synthesis of a modern antiepileptic preparation lamotrigine, as an example.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 3, pp. 713–719, March, 2005. |
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| Keywords: | destruction 3 5-diamino-1 2 4-triazines condensation |
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