Novel macrocyclic templates by ring enlargement of ansa-steroids |
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| Authors: | Stefan B urle, Thorsten Blume, Emmanuel Leroy, Anne Mengel, Christian Parchmann, Kathrin Schmidt,Werner Skuballa |
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| Affiliation: | aSchering AG, Medicinal Chemistry, Research Center Europe, 13342 Berlin, Germany |
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| Abstract: | Ring enlargement of ansa-steroids leads to a variety of novel templates which are suitable for the preparation of diverse libraries of natural product derivatives. Key steps for the synthesis of these highly functionalized templates were either an ozonolysis-derivatization-ring closing metathesis-sequence or a macrolactonization. |
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| Keywords: | Steroids Macrocycles Ring closing metathesis Macrolactonization Template |
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