Molecular imprinting of β-cyclodextrin/cholesterol template into a silica polymer for cholesterol separation |
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| Authors: | Cleide Mara Faria Soares Gisella Maria Zanin Flavio Faria de Moraes Onélia Aparecida Andreo dos Santos Heizir Ferreira de Castro |
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| Institution: | (1) Process Engineering Program, Institute of Science and Technology, Tiradentes University, Aracaju, SE, Brazil;(2) Department of Chemical Engineering, Universidade Estadual de Maringá, 87020-900 Maringa, PR, Brazil;(3) Department of Chemical Engineering, Faculdade de Engenharia Química de Lorena, Lorena, SP, Brazil |
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| Abstract: | The molecular assembly formed by the inclusion complex of cholesterol in β-cyclodextrin (β-CD:chol) was used as a template
for the molecular imprinting of a sol–gel polymer (MIP/β-CD:chol), produced with tetraethoxysilane (TEOS) as precursor. The
MIP/β-CD:chol and pure silica matrix (PSM) were tested for the efficiency of cholesterol removal from solutions at different
cholesterol concentrations (1–10 mg/mL). The adsorption tests were run at 25°C using 1% (w/v) solid/liquid suspensions during
24 h. The MIP/β-CD:chol data on cholesterol adsorption was fitted by the Langmüir isotherm model, giving a maximum adsorption
capacity of 76.5 mg cholesterol/g-adsorbent. The PSM data did conform to the Langmüir model. The maximum cholesterol adsorption
achieved with the PSM was higher, 251 mg/g, probably due to multilayer adsorption. The hydrophobic silica matrix, imprinted
with the inclusion complex of β-CD and a target molecule, has the potential of being used as an adsorbent for other organic
molecules. |
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| Keywords: | Adsorption Cholesterol Molecular imprinting Silica Sol– gel Tetraethoxysilane β -Cyclodextrin |
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