ESR DETECTION OF ENDOGENOUS ASCORBATE FREE RADICAL IN MOUSE SKIN: ENHANCEMENT OF RADICAL PRODUCTION DURING UV IRRADIATION FOLLOWING TOPICAL APPLICATION OF CHLORPROMAZINE |
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| Authors: | Garry R. Buettner Ann G. Motten Robert D. Hall Colin F. Chignell |
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| Affiliation: | Laboratory of Molecular Biophysics National Institute of Environmental Health Sciences PO Box 12233 Research Triangle Park, NC 27709, USA |
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| Abstract: | Using electron spin resonance spectroscopy, we observed that UV radiation (330 nm) increased the endogenous ascorbate free radical concentration in hairless mouse (HRS/J) skin. When the skin was topically treated with a chlorpromazine solution prior to illumination, UV irradiation caused the ascorbate free radical concentration to increase even more. This observation suggests that there is an increased UV-induced oxidative stress in the presence of chlorpromazine, probably caused by the production of free radicals from chlorpromazine. |
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