An approach to the core structure of leiodermatolide |
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Authors: | Rink Christian Navickas Vaidotas Maier Martin E |
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Institution: | Institut fu?r Organische Chemie, Universita?t Tu?bingen, Auf der Morgenstelle 18, 72076 Tu?bingen, Gemany. |
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Abstract: | The synthesis of the 16-membered core structure of leiodermatolide 40 has been achieved in 26 linear steps starting from (R)-Roche ester. The key steps in the synthesis of 40 are a Stille cross-coupling between two main fragments 11 and 33 having roughly equal size. For the trisubstituted C4/C5 double bond a carbometalation reaction followed by a Suzuki coupling was used. A Yamaguchi macrolactonization furnished macrolactone 39. |
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