TsCl-promoted sulfonylation of quinoline N-oxides with sodium sulfinates in water |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China;2. Qinghai Provincial Key Laboratory of Tibetan Medicine Research and Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Qinghai 810008, China |
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| Abstract: | An eco-friendly protocol for the synthesis of various 2-sulfonyl quinolines/pyridines through sulfonylation of heteroaromatic N-oxides with sodium sulfinates in water at ambient temperature under metal- and oxidant-free conditions has been developed. The mild reaction conditions, high reaction efficiency, operational simplicity, short reaction time and remarkable functional-group compatibility make the developed protocol very attractive for the preparation of 2-sulfonyl N-heteroaromatic compounds. |
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| Keywords: | 2-Sulfonylquinolines Sodium sulfinates Sulfonylation In water |
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