Recent progress in nanomaterial-enhanced fluorescence polarization/anisotropy sensors |
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| Authors: | Jia Chen Juewen Liu Xingguo Chen Hongdeng Qiu |
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| Affiliation: | 1. CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2. University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 10039, China;3. Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada;4. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China;1. Department of Life Science Engineering, Faculty of New Sciences & Technologies, University of Tehran, Tehran, Iran;2. Department of Biotechnology, Payame Noor University, Tehran, Iran;3. Department of Biochemistry, Tarbiat Modares University, Tehran, Iran;4. Center of Excellence in Electrochemistry, Faculty of Chemistry, University of Tehran, Tehran, Iran;5. Biosensor Research Center, Endocrinology & Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;1. Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, 400715 Chongqing, PR China;2. College of Pharmaceutical Sciences, Southwest University, 400715 Chongqing, PR China;1. Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Normal University, Guilin 541004, China;2. School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China;1. Department of Chemistry, Liaocheng University, Liaocheng 252059, PR China;2. Shandong Provincial Key Lab of Test Technology on Food Quality and Safety, Shandong Academy of Agricultural Sciences, Jinan 250100, PR China |
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| Abstract: | As a promising signaling transduction approach, fluorescence polarization (FP)/fluorescence anisotropy (FA), provides a powerful quantitative tool for the rotational motion of fluorescently labeled molecules in chemical or biological homogeneous systems. Unlike fluorescence intensity, FP/FA is almost independent the concentration or quantum of fluorophores, but they are highly dependent on the size or molecular weight of the molecules or materials attached to fluorophores. Recently, significant progress in FP/FA was made, due to the introduction of some nanomaterials as FP/FA enhancers. The detection sensitivity is thus greatly improved by using nanomaterials as FP/FA enhancers, and nanomaterial-based FP/FA is currently used successfully in immunoassay, and analysis of protein, nucleic acid, small molecule and metal ion. Nanomaterial-based FP/FA provides a new kind of strategy to design fluorescent sensors and establishes innovative analytical methods. In this review, we summarize the scientific publications in the field of FP/FA sensor in recent five years, and first introduce the recent progress of FP/FA sensor based on nanomaterial. Subsequently, the various analytical applications of FP/FA based on nanomaterial are discussed. Finally, we provide perspectives on the current challenges and future prospects in this promising field. |
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| Keywords: | Fluorescence polarization/anisotropy Nanomaterials Sensor Recent progress Application |
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