Functional delivery vehicle of organic nanoparticles in inorganic crystals |
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| Institution: | 1. College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China;2. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China;3. State Key Lab of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China;1. Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310002, China;2. Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310002, China;3. Zhejiang University Cancer Center, Zhejiang University, Hangzhou 310002, China;4. School of Basic Medical Sciences, Institute of Hypoxia Medicine, Wenzhou Medical University, Wenzhou 325035, China;5. College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, China;6. Department of Medical Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China |
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| Abstract: | Encapsulation of bioactive substances for extended shelf life and controlled, targeted release is critical for their applications in food and drug delivery. Here, a new method has been developed to encapsulate bioactive molecules in the crystal composites, showing greatly enhanced stability and unique pH-triggered response. Chlorophyll, a model bioactive, is first loaded in shellac nanoparticles via co-precipitation with a high encapsulation efficiency, and then the chlorophyll-loaded nanoparticles are incorporated into calcite crystals grown from a gel media containing the nanoparticles. Under the protection of shellac nanoparticles and calcite crystals, chlorophyll shows excellent stability even under light. Encapsulated chlorophyll could only be released by first dissolving the calcite crystals under acidic condition and then dissolving the shellac nanoparticles under alkaline condition. The unique pH-triggered release mimics the pH change from acidic in the stomach to alkaline in the intestine and is thus well suited for controlled, targeted intestinal release. This work suggests that the crystal composites are an ideal delivery vehicle for the functional design of bioactive molecules. |
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| Keywords: | Nanoparticle Calcite crystal Encapsulation Chlorophyll Dual-pH responses |
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