Copper Hydride Catalyzed Hydroamination of Alkenes and Alkynes |
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Authors: | Dr Michael T Pirnot Dr Yi‐Ming Wang Prof Dr Stephen L Buchwald |
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Institution: | Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA) |
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Abstract: | Over the past few years, CuH‐catalyzed hydroamination has been discovered and developed as a robust and conceptually novel approach for the synthesis of enantioenriched secondary and tertiary amines. The success in this area of research was made possible through the large body of precedent in copper(I) hydride catalysis and the well‐explored use of hydroxylamine esters as electrophilic amine sources in related copper‐catalyzed processes. This Minireview details the background, advances, and mechanistic investigations in CuH‐catalyzed hydroamination. |
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Keywords: | asymmetric catalysis chiral amine synthesis copper catalysis copper(I) hydride hydroamination |
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