Enantioselective C−H Olefination of α‐Hydroxy and α‐Amino Phenylacetic Acids by Kinetic Resolution |
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| Authors: | Dr Kai‐Jiong Xiao Ling Chu Prof?Dr Jin‐Quan Yu |
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| Institution: | Department of Chemistry, The Scripps Research Institution, La Jolla, CA, USA |
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| Abstract: | Significant progress has been made in the past decade regarding the development of enantioselective C?H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C?H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)‐catalyzed enantioselective C?H activation and C?C bond formation, thus significantly expanding the scope of enantioselective C?H activation reactions. |
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| Keywords: | amino acids C− H activation enantioselectivity kinetic resolution palladium |
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