Palladium‐Catalyzed Regioselective Diarylation of o‐Carboranes By Direct Cage B−H Activation |
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Authors: | Dr Yangjian Quan Prof?Dr Zuowei Xie |
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Institution: | Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China |
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Abstract: | Palladium‐catalyzed intermolecular coupling of o‐carborane with aromatics by direct cage B?H bond activation has been achieved, leading to the synthesis of a series of cage B(4,5)‐diarylated‐o‐carboranes in high yields with excellent regioselectivity. Traceless directing group ‐COOH plays a crucial role for site‐ and di‐selectivity of such intermolecular coupling reaction. A PdII–PdIV–PdII catalytic cycle is proposed to be responsible for the stepwise arylation. |
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Keywords: | arylation B-H activation carborane coupling reactions homogeneous catalysis |
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