Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible‐Light Photoredox Catalysis |
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| Authors: | Jian Rong Ling Deng Ping Tan Dr Chuanfa Ni Dr Yucheng Gu Prof Dr Jinbo Hu |
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| Institution: | 1. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China;2. Syngenta, Jealott's Hill International Research Centre, Bracknell, Berkshire, UK;3. http://hujinbo.sioc.ac.cn/en/ |
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| Abstract: | The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible‐light photoredox catalysis. A wide range of readily available mono‐, di‐, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalkylation reagents under mild conditions. This method not only describes a new synthetic application of fluorinated sulfones, but also provides a new route to fluoroalkyl radicals. |
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| Keywords: | fluorine isocyanides photoredox catalysis radical reactions sulfones |
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