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HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium‐Catalyzed Cross‐Couplings in Water at Room Temperature |
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| Authors: | Dr Sachin Handa Prof?Dr Martin P Andersson Dr Fabrice Gallou Dr John Reilly Prof?Dr Bruce H Lipshutz |
| Institution: | 1. Department of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA;2. Nano-Science Center, Department of Chemistry, University of Copenhagen, Denmark;3. Novartis Pharma AG, Basel, Switzerland;4. Novartis Institute for Medical Research, Cambridge, MA, USA |
| Abstract: | The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd‐catalyzed cross‐couplings to be run using ≤1000 ppm of this pre‐catalyst. Applications to Suzuki–Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures. Comparisons with existing state‐of‐the‐art ligands and catalysts are discussed herein. |
| Keywords: | E Factor green chemistry ligand design micellar catalysis Suzuki– Miyaura coupling |