Copper‐Catalyzed Borylative Cross‐Coupling of Allenes and Imines: Selective Three‐Component Assembly of Branched Homoallyl Amines |
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Authors: | Dr James Rae Kay Yeung Dr Joseph J W McDouall Prof Dr David J Procter |
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Institution: | School of Chemistry, University of Manchester, Manchester, UK |
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Abstract: | A copper‐catalyzed three‐component coupling of allenes, bis(pinacolato)diboron, and imines allows regio‐, chemo‐, and diastereoselective assembly of branched α,β‐substituted‐γ‐boryl homoallylic amines, that is, products bearing versatile amino, alkenyl, and borane functionality. Alternatively, convenient oxidative workup allows access to α‐substituted‐β‐amino ketones. A computational study has been used to probe the stereochemical course of the cross‐coupling. |
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Keywords: | allenes boron copper cross-coupling imines |
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