Oligonucleotide‐Based Mimetics of Hepatocyte Growth Factor |
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| Authors: | Dr. Ryosuke Ueki Ayaka Ueki Naoto Kanda Prof. Shinsuke Sando |
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| Affiliation: | Department of Chemistry and Biotechnology, The University of Tokyo, Bunkyo-ku, Tokyo, Japan |
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| Abstract: | Oligonucleotide‐based hepatocyte growth factor (HGF) mimetics are described. A DNA aptamer to Met, a cognate receptor for HGF, was shown to induce Met activation when used in dimer form. The most potent aptamer dimer, ss‐0, which was composed solely of 100‐mer single‐stranded DNA, exhibited nanomolar potency. Aptamer ss‐0 reproduced HGF‐induced cellular behaviors, including migration and proliferation. The present work sheds light on oligonucleotides as a novel chemical entity for the design of growth factor mimetics. |
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| Keywords: | aptamers DNA nanotechnology growth factors receptors signal transduction |
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