Ruthenium(0)‐Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with α‐Ketols: Convergent Construction of Angucycline Ring Systems |
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| Authors: | Dr. Aakarsh Saxena Dr. Felix Perez Prof. Michael J. Krische |
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| Affiliation: | University of Texas at Austin, Department of Chemistry, Austin, TX, USA |
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| Abstract: | Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C?C coupling of acetylenic aldehydes with α‐ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type II polyketide ring systems of the angucycline class. |
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| Keywords: | cycloaddition hydrogenation natural products polyketides ruthenium |
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