Ligand‐Promoted Borylation of C(sp3)H Bonds with Palladium(II) Catalysts |
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| Authors: | Jian He Heng Jiang Ryosuke Takise Ru‐Yi Zhu Dr. Gang Chen Prof. Dr. Hui‐Xiong Dai Dr. T. G. Murali Dhar Dr. Jun Shi Dr. Hao Zhang Dr. Peter T. W. Cheng Prof. Dr. Jin‐Quan Yu |
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| Affiliation: | 1. Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA);2. Discovery Chemistry, Bristol‐Myers Squibb Company, Route 206 and Provinceline Road, Princeton, NJ 08543 (USA);3. Discovery Chemistry, Bristol‐Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA) |
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| Abstract: | A quinoline‐based ligand effectively promotes the palladium‐catalyzed borylation of C(sp3)? H bonds. Primary β‐C(sp3)? H bonds in carboxylic acid derivatives as well as secondary C(sp3)? H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)‐ and rhodium(I)‐catalyzed C? H borylation reactions in terms of scope and operational conditions. |
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| Keywords: | amino acids borylation C H activation palladium synthetic methods |
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