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An Improved System for the Aqueous Lipshutz–Negishi Cross‐Coupling of Alkyl Halides with Aryl Electrophiles |
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| Authors: | Dr. Vasudev R. Bhonde Dr. Brian T. O'Neill Prof. Dr. Stephen L. Buchwald |
| Affiliation: | 1. Department of Chemistry, Room 18–490, Massachusetts Institute of Technology, Cambridge, MA, USA;2. Pfizer Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Groton, CT, USA |
| Abstract: | The development of a palladacyclic precatalyst supported by a new biaryl(dialkyl)phosphine ligand (VPhos) in combination with octanoic acid/sodium octanoate as a simple and effective surfactant system provided an improved catalyst system for the rapid construction of a broad spectrum of alkylated scaffolds from alkyl zinc reagents generated in situ. |
| Keywords: | alkyl zinc reagents cross-coupling micelles palladium precatalysts surfactants |