Expedient Iron‐Catalyzed C−H Allylation/Alkylation by Triazole Assistance with Ample Scope |
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Authors: | Dr Gianpiero Cera Tobias Haven Prof?Dr Lutz Ackermann |
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Institution: | 1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universit?t, G?ttingen, Germany;2. http://www.ackermann.chemie.uni‐goettingen.de |
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Abstract: | Triazole assistance set the stage for a unified strategy for the iron‐catalyzed C?H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site‐selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole‐assisted C?H activation proceeded chemo‐, site‐, and diastereo‐selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions. |
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Keywords: | alkylation allylation C− H activation iron triazoles |
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