首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Stereoselective Arene‐Forming Aldol Condensation: Synthesis of Configurationally Stable Oligo‐1,2‐naphthylenes
Authors:Dominik Lotter  Dr Markus Neuburger  Dr Michel Rickhaus  Priv‐Doz?Dr Daniel Häussinger  Dr Christof Sparr
Institution:1. Department of Chemistry, University of Basel, Basel, Switzerland;2. http://www.chemie.unibas.ch/~sparr
Abstract:Structurally well‐defined oligomers are fundamental for the functionality of natural molecular systems and key for the design of synthetic counterparts. Herein, we describe a strategy for the efficient synthesis of individual stereoisomers of 1,2‐naphthylene oligomers by iterative building block additions and consecutive stereoselective arene‐forming aldol condensation reactions. The catalyst‐controlled atropoenantioselective and the substrate‐controlled atropodiastereoselective aldol condensation reaction provide structurally distinct ter‐ and quaternaphthalene stereoisomers, which represent configurationally stable analogues of otherwise stereodynamic, helically shaped ortho‐phenylenes.
Keywords:aldol reactions  atropisomerism  configurational stability  oligonaphthylenes  stereoselectivity
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号