Asymmetric Conjugate Alkynylation of Cyclic α,β‐Unsaturated Carbonyl Compounds with a Chiral Diene Rhodium Catalyst |
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| Authors: | Dr Xiaowei Dou Dr Yinhua Huang Prof?Dr Tamio Hayashi |
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| Institution: | 1. Department of Chemistry, National University of Singapore, Singapore, Singapore;2. Institute of Materials Research and Engineering, A*STAR, Singapore, Singapore |
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| Abstract: | Asymmetric conjugate alkynylation of cyclic α,β‐unsaturated carbonyl compounds (ketones, esters, and amides) was realized by use of diphenyl(triisopropylsilyl)ethynyl]methanol as an alkynylating reagent in the presence of a rhodium catalyst coordinated with a new chiral diene ligand (Fc‐bod; bod=bicyclo2.2.2]octa‐2,5‐diene, Fc=ferrocenyl) to give high yields of the corresponding β‐alkynyl‐substituted carbonyl compounds with 95–98 % ee. |
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| Keywords: | alkynes asymmetric catalysis diene ligands rhodium synthetic methods |
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