Electrocatalytic Generation of Amidyl Radicals for Olefin Hydroamidation: Use of Solvent Effects to Enable Anilide Oxidation |
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| Authors: | Lin Zhu Peng Xiong Zhong‐Yi Mao Yong‐Heng Wang Prof. Dr. Xiaomei Yan Prof. Dr. Xin Lu Prof. Dr. Hai‐Chao Xu |
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| Affiliation: | 1. Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, P. R. China;2. http://chem.xmu.edu.cn/kydw_ktz/hcxu/index.htm 0000-0002-3008-5143 Collaborative Innovation Center of Chemistry for Energy Material, Key Laboratory of Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen, P. R. China |
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| Abstract: | Oxidative generation of synthetically important amidyl radicals from N?H amides is an appealing and yet challenging task. Previous methods require a stoichiometric amount of a strong oxidant and/or a costly noble‐metal catalyst. We report herein the first electrocatalytic method that employs ferrocene (Fc), a cheap organometallic reagent, as the redox catalyst to produce amidyl radicals from N‐aryl amides. Based on this radical‐generating method, an efficient intramolecular olefin hydroamidation reaction has been developed. |
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| Keywords: | amidyl radicals electrochemistry ferrocene hydroamidation redox catalysts |
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