Reaction of Diazo Compounds with Difluorocarbene: An Efficient Approach towards 1,1‐Difluoroolefins |
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| Authors: | Zhikun Zhang Weizhi Yu Chenggui Wu Chengpeng Wang Yan Zhang Prof. Dr. Jianbo Wang |
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| Affiliation: | 1. Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China);2. The State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032 (China) |
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| Abstract: | A transition‐metal‐free difluoromethylenation of diazo compounds that proceeds under mild conditions has been developed and is based on the use of TMSCF2Br as the difluoromethylene source and tetrabutylammonium bromide (TBAB) as the promoter. The chemoselective formal carbene dimerization reaction is achieved owing to the electronic properties and the relative stability of the difluorocarbene intermediate. |
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| Keywords: | carbenes diazo compounds difluorocarbene fluorine hydrazones |
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