Recognition and Sensing of Creatinine |
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| Authors: | Dr Tomàs Guinovart Daniel Hernández‐Alonso Dr Louis Adriaenssens Dr Pascal Blondeau Dr Marta Martínez‐Belmonte Prof F Xavier Rius Dr Francisco J Andrade Prof Pablo Ballester |
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| Institution: | 1. Department of Analytical and Organic Chemistry, Rovira i Virgili University, Tarragona, Spain;2. Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Tarragona, Spain;3. School of Chemistry, University of Lincoln, Lincoln, UK;4. Catalan Institute of Research and Advanced Studies, Barcelona, Spain |
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| Abstract: | Current methods for creatinine quantification suffer from significant drawbacks when aiming to combine accuracy, simplicity, and affordability. Here, an unprecedented synthetic receptor, an aryl‐substituted calix4]pyrrole with a monophosphonate bridge, is reported that displays remarkable affinity for creatinine and the creatininium cation. The receptor works by including the guest in its deep and polar aromatic cavity and establishing directional interactions in three dimensions. When incorporated into a suitable polymeric membrane, this molecule acts as an ionophore. A highly sensitive and selective potentiometric sensor suitable for the determination of creatinine levels in biological fluids, such as urine or plasma, in an accurate, fast, simple, and cost‐effective way has thus been developed. |
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| Keywords: | cavitands creatinine ionophores molecular recognition sensors |
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