Meningiomas: Preoperative predictive histopathological grading based on radiomics of MRI |
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Institution: | 1. Department of Radiology, Zhongshan Hospital of Fudan University, Fudan University, No 130, Dongan Rd, Xuhui District, Shanghai, 200032, P.R. of China;2. Xuzhou Mining Group General Hospital, radiology department, Xuzhou, Jiangsu, 221000, P.R. of China;3. Shanghai Aitrox Technology Corporation Limited, Shanghai, 200032, P.R. of China;4. Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital of Fudan University, Fudan University, No 130, Dongan Rd, Xuhui District, Shanghai, 200032, P.R. of China;5. Department of Radiology, Zhongshan Hospital of Fudan University, Fudan University;6. Department of Radiology, Zhongshan Hospital of Fudan University, Fudan University, No138, Fenglin Rd, Xuhui District, Shanghai, 200032, P.R. of China;1. Department of Radiology, Huzhou Central Hospital, Huzhou, China;2. Department of Radiology, Jiangxi Provincial People''s Hospital, Nanchang 330006, China;3. GE Healthcare, Hangzhou, China |
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Abstract: | PurposeWe aimed to develop a radiomics model to predict the histopathological grading of meningiomas by magnetic resonance imaging (MRI) before surgery.MethodsWe recruited 131 patients with pathological diagnosis of meningiomas. All the patients had undergone MRI before surgery on a 3.0 T MRI scanner to obtain T1 fluid- attenuated inversion recovery (T1 FLAIR) images, T2-weighted images (T2WI) and T1 FLAIR with contrast enhancement (CE-T1 FLAIR) images covering the whole brain. The removing features with low variance, univariate feature selection, and least absolute shrinkage and selection operator (LASSO) were used to select radiomics features. Six classifiers were used to train the models (logistic regression (LR), k-nearest neighbor (KNN), decision tree (DT), support vector machine (SVM), random forests (RF), and XGBoost), and then 24 models were established using a random verification method to differentiate low-grade from high-grade meningiomas. The performance was assessed by receiver-operating characteristic (ROC) analysis, the f1-score, sensitivity, and specificity.ResultsThe radiomics features were significantly associated with the histopathological grading. Quantitative imaging features (n = 1409) were extracted, and nine features were selected to predict the grades of meningiomas. The best performance of the radiomics model for the degree of differentiation was obtained by SVM (area under the curve (AUC), 0.956; 95% confidence interval (CI), 0.83–1.00; sensitivity, 0.87; specificity, 0.92; f1-score, 0.90).ConclusionThe radiomics models are of great value in predicting the histopathological grades of meningiomas, and have broad prospects in radiology and clinics. |
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